Complementary/alternative therapies for premenstrual syndrome: a systematic review of randomized controlled trials (Structured abstract). View abstract. 2020;27(12):4844-4852. 1990;1(4):199-201. The potential for dietary supplements to reduce premenstrual syndrome (PMS) symptoms. Evening primrose oil may increase the risk of bleeding in people wi… Effect of primrose oil on serum lipids and blood pressure in hyperlipidemic subjects. Compare the effect of flaxseed, evening primrose oil, and Vitamin E on duration of periodic breast pain. Zhong Xi Yi Jie He Za Zhi. Kelley, K. W. and Carroll, D. G. Evaluating the evidence for over-the-counter alternatives for relief of hot flashes in menopausal women. Dr. Ed Friedlander answered. Most of the time it happens because the dose is too high. Vaddadi KS. Br J Clin Pharmacol 1985;19:335-42. View abstract. Mr. Picincu is a regular contributor to these platforms where she either provides health-related content or coaching to those who are interested in achieving a balanced lifestyle. 2004;11(1):11-33. View abstract. Phytother Res 2012;26:265-272. Cameron, M., Gagnier, J. J., Little, C. V., Parsons, T. J., Blumle, A., and Chrubasik, S. Evidence of effectiveness of herbal medicinal products in the treatment of arthritis. Lets take a look at other precautions to be mindful of when using evening primrose oil. View abstract. When taken in appropriate amounts short term, oral use of evening primrose oil is most likely safe.Evening primrose oil can cause: 1. EPO may contribute to pregnancy complications and increased bleeding in people taking warfarin and other blood-thinning drugs. 2016 Mar;51(3):349-56. Whitaker DK, Cilliers J, de Beer C. Evening primrose oil (Epogam) in the treatment of chronic hand dermatitis: disappointing therapeutic results. Lancet 5-10-1986;1(8489):1098. 1978;17(2):67-76. Shaw D, Leon C, Kolev S, Murray V. Traditional remedies and food supplements: a 5-year toxicological study (1991-1995). 1993;27(12):1475-1477. The use of gamma linolenic acid in the prevention and treatment of diabetic neuropathy. J Abnorm Child Psychol 1987;15:75-90. Proc.2nd International Symposium on Premenstrual, Postpartum and Menopausal Mood Disorders 1987;abstract 44. Kwon HS, Lee JH, Kim GM, Choi EH, Bae JM. J Obstet.Gynaecol.Can 2006;28(1):49-71. Jones, L. Essential Fatty Acids and Dry Eye: What Do We Know? In clinical trials, it has been shown to relieve morning stiffness and reduce the need for medications in rheumatoid arthritis sufferers, according to results published in the journal Advances in Pharmacological Sciences in May 2016. Br J Rheumatol 1991;30(5):370-372. A., Roelfsema, H., Zecevic, J., Graham, T. E., and Holub, B. J. Horrobin, D. F. Multiple sclerosis: the rational basis for treatment with colchicine and evening primrose oil. 2003;16(1):47-57. Br J Rheumatol 1991;30(5):370-372. Hansen TM, Lerche A, Kassis V, et al. Proc.2nd International Symposium on Premenstrual, Postpartum and Menopausal Mood Disorders 1987;abstract 47. Vermani, M., Milosevic, I., Smith, F., and Katzman, M. A. Tomczyk, M., Zovko-Koncic, M., and Chrostek, L. Phytotherapy of alcoholism. A prospective, double-blind, placebo-controlled multicentre clinical trial. Veselinovic M, Vasiljevic D, Vucic V, et al. View abstract. Morse PF, Horrobin DF, Manku MS, et al. View abstract. However, it is not recommended that you take this oil supplement for long periods of time. This information may not fit your specific health circumstances. Ernst E. Premenstrual syndrome: Does evening primrose oil have a therapeutic effect? Holist.Nurs.Pract. View abstract. 2004;79(3):353-372. Prog Lipid Res 1992;31(2):163-194. Evening primrose oil side effects may include headaches, nausea, stomach pain and digestive distress as well as more serious issues, such as lipoid pneumonia. Evening primrose oil (Efamol) in the treatment of children with atopic eczema. Kleijnen J. Bates D, Fawcett PRW, Shaw DA, and et all. View abstract. View abstract. Part 2: Rheumatoid arthritis. A study of evening primrose seed oil in atopic asthma. delicate wildflower native to North America and is not a true primrose View abstract. This oil has a number of medicinal uses and hence, is widely used in the management of several disorders. A double-blind trial of essential fatty acid supplementation in patients with tardive dyskinesia. 2003;139(1):21. Phytother.Res 2009;23(12):1647-1662. Some early research shows that adding evening primrose and fish oil to regular infant formula might provide levels of some types of fats that are closer to those in breast milk. Early research shows that taking 18 grams of evening primrose per day does not affect liver size or survival in people with liver cancer. North American Menopause Society. Am J Clin Nutr 2000;71:352S-6S. A randomized, double-blind, placebo-controlled trial to evaluate efficacy and tolerability of an optimized botanical combination in the management of patients with primary hypercholesterolemia and mixed dyslipidemia. Cortisone in ulcerative colitis. Medications used during surgery (Anesthesia) interacts with EVENING PRIMROSE OIL. Gimenes, O. M., da Silva, M. J., and Benko, M. A. Proc.2nd International Symposium on Premenstrual, Postpartum and Menopausal Mood Disorders 1987;abstract 46. Can Fam.Physician 2002;48:1789-1797. Lis-Balchin, M. Parallel placebo-controlled clinical study of a mixture of herbs sold as a remedy for cellulite. It also doesn't appear to reduce the risk of developing high blood pressure in pregnant women when taken with fish oil. J Educ Health Promot. View abstract. View abstract. View abstract. Kalati M, Kashanian M, Jahdi F, Naseri M, Haghani H, SHeikhansari N. Evening primrose oil and labour, is it effective? A learning disorder marked by difficulty reading (dyslexia). The reported side effects that occur with evening primrose oil use include: nausea, headache; indigestion; stomach pain; soft stools; Stomach discomfort and loose stools may be indications that the dosage is too high. Parveen, S. Sarwar G. Ali M. Channa G. A. Danazol versus oil of evening primrose in the treatment of mastalgia. Hederos CA, Berg A. Epogam evening primrose oil treatment in atopic dermatitis and asthma. Cant A, Shay J, Horrobin DF. Casper RF and Powell AM. Lindmark L and Clough P. A 5-month open study with long-chain polyunsaturated fatty acids in dyslexia. Lancet 1-31-1981;1(8214):278. This remedy may also interact with anticonvulsants, according to an April 2018 report in Pharmacy Today. View abstract. J Am Diet Assoc 2000;100:1368-80. View abstract. Arzneimittelforschung 2005;55(11):669-676. Read more: 8 Warning Signs of Depression You Shouldn't Ignore. © 2005 - 2019 WebMD LLC. View abstract. Reduction of 5-azacitidine induced skin reactions in MDS patients with evening primrose oil. Montreal, Quebec: Eden;1982. Wolkin, A., Jordan, B., Peselow, E., Rubinstein, M., and Rotrosen, J. These medications are commonly prescribed to those suffering from depression. Some research shows that taking evening primrose oil can decreases. Dr. Ed Friedlander answered. Johnson, S. R. Premenstrual syndrome therapy. Fortschritte der Medizin 1991;109(19):11. J Fam.Pract. 2017 Dec;42(8):923-25. ).Some health conditions may make you more susceptible to the side-effects of the drug. Moodley J and Norman RJ. Soeken, K. L., Miller, S. A., and Ernst, E. Herbal medicines for the treatment of rheumatoid arthritis: a systematic review. Mansel RE, Pye JK, and Hughes LE. Journal of Holistic Medicine. To be on the safe side, you should stop taking evening primrose oil at least 2 weeks before surgery. Never delay or disregard seeking professional medical advice from your doctor or other qualified health care provider because of something you have read on WebMD. Down the primrose path: petechiae in a neonate exposed to herbal remedy for parturition. Biagi PL, Bordoni A, Hrelia S, et al. But taking evening primrose oil doesn't seem to improve finger temperature or spasm of the blood vessels caused by cold. Neurol.Res 2008;30(7):710-719. Nutr Cancer 1995;24:33-45. . J Pediatr 2008;152:140, 140.e1. View abstract. Gamma-linolenic acid for attention-deficit hyperactivity disorder: Placebo-controlled comparison to D-amphetamine. Ann.Pharmacother. Lancet 1-28-1995;345(8944):260-261. Acta Neurol Scand 1990;82:209-16. Dark adaptation, motor skills, docosahexaenoic acid, and dyslexia. View abstract. Menopause. Caution is advised in people taking drugs or herbs and supplements that lower blood pressure. But there isn't enough information to know if evening primrose oil or the other medications caused the seizure. Effects of safflower oil and evening primrose oil in men with a low dihomo-gamma-linolenic level. If you're under medical treatment, ask your health care provider about the safety of evening primrose. Arzneimittelforschung 2006;56(8):574-581. View abstract. The Medicines Control Agency (MCA), Epogam and Efamast (gamolenic acid) - withdrawal of marketing authorizations. View abstract. Humphreys F, Symons J, Brown H, and et al. J Clin Immunol 2002;22:83-91. View abstract. The use of Evening Primrose Oil is … Pakistan Journal of Surgery. 2009;58(10):552-559. 2010;50(5):e106-e115. Purewal TS, Evans PMS, Havard F, O'Hare JP. Br J Surg. Abraham RD, Riemersma RA, Elton RA, et al. Evening primrose oil may cause low blood pressure. Health Technol Assess 2000;4(37):1-191. The basic side effects of evening primrose are rare and include the mild cases of stomach pain, headaches, nausea, and diarrhea. Zhong Xi Yi Jie He Za Zhi 1991;11:20-2, 4. View abstract. Human Psychopharmacology 1991;6(253):256. Acta Neurol Scand 1999;99:112-6. Prostaglandins Leukot.Essent.Fatty Acids 1993;49(4):809-814. Sharma N, Gupta A, Jha PK, Rajput P. Mastalgia cured! Horrobin, D. F. Nutritional and medical importance of gamma-linolenic acid. Clinical observation of Blackcurrant oil Soft Capsule and Evening primrose oil Soft Capsule in treating hyperlipidemia. Clin Exp Hypertens B 1983;2:247-54. Premenstrual syndrome (PMS). Cochrane Database.Syst.Rev. McFayden, I. J., Forrest, A. P., Chetty, U., and Raab, G. Cyclical breast pain--some observations and the difficulties in treatment. Horrobin, D. F. Lipids and schizophrenia. This copyrighted material is provided by Natural Medicines Comprehensive Database Consumer Version. Ann Med Psychol (Paris) 1983;141(8):883-891. Behan PO, Behan WM, Horrobin D. Effect of high doses of essential fatty acids on the postviral fatigue syndrome. 1990;77(10):1110-1112. Gupta H, Pawar D, Riva A, et al. Water warts. Girman, A., Lee, R., and Kligler, B. View abstract. Acta Derm Venereol Suppl (Stockh) 1985;114:143-145. Menopause: a review of botanical dietary supplements (;Provisional abstract). On top of that, it may not be safe for individuals with bleeding disorders and those preparing for surgery. View abstract. BMJ 2003;327:1358-9. It's not clear if this benefit results from evening primrose or fish oil. Soulairac, A., Lambinet, H., and Neuman, J. C. [Schizophrenia and prostaglandins. View abstract. Takwale A, Tan E, Agarwal S, et al. Bendich A. Kiehl R, Ionescu G, Manuel P, and et al. View abstract. Phytother.Res. Evening primrose oil contains GLA (gamma-linolenic acid). Attempts at dietary alteration of prostaglandin pathways in the management of pre-eclampsia. Nat.Prod.Commun. Interactions between essential fatty acids and steroid hormones. 44 years experience Pathology. 1988;7(1):S189. View abstract. Joy, C. B., Mumby-Croft, R., and Joy, L. A. Polyunsaturated fatty acid (fish or evening primrose oil) for schizophrenia. Br Med Bull. View abstract. Fugate, S. E. and Church, C. O. Nonestrogen treatment modalities for vasomotor symptoms associated with menopause. Prostaglandins and premenstrual syndrome. For professional medical information on natural medicines, see Natural Medicines Comprehensive Database Professional Version.© Therapeutic Research Faculty . Arch Gynecol.Obstet 2007;276(5):463-469. J dermatol treat. 2012;3, Centre for Reviews and Dissemination. Br J Psychiatry 1999;175:88. Effects of gamma-linolenic acid and oleic acid on paclitaxel cytotoxicity in human breast cancer cells. Evening primrose hypertension hope. Aust N Z J Surg 1994;64(5):329-331. Supplement manufacturers claim that it may reduce fatigue, clear acne, promote weight loss and improve asthma symptoms. View abstract. View abstract. Evidence-based treatment in family practice. Jamal GA and Carmichael H. The effects of gamma-linolenic acid on human diabetic peripheral neuropathy: a double-blind placebo-controlled trial. Prostaglandins Leukot Essent Fatty Acids 1993;49:691-4. Ishikawa T, Fujiyama Y, Igarashi O, Morino M, Tada N, Kagami A, Sakamoto T, Nagano M, and Nakamura H. Effects of gammalinolenic acid on plasma lipoproteins and apolipoproteins. Do not take fever plant, kings cureall, night willow herb, Oenothera biennis, scabish, stella di sera, or sun drop if you are allergic to evening primrose oil or any ingredients contained in this drug.. Keep out of reach of children. Eur J Gastroenterology and Hepatology 1991;3(1):87-90. and 1981;3(2):118-139. Essential fatty acids in the treatment of premenstrual syndrome. Prostaglandins Med 1981;6(4):375-379. Information from this source is evidence-based and objective, and without commercial influence. A recent review analyzed several anti-inflammatory herbal medicines, including evening primrose oil. Ty-Torredes KA. Prevention of nerve conduction deficit in diabetic rats by polyunsaturated fatty acids. View abstract. View abstract. View abstract. Barrett S. Primrose oil and eczema: How research was promoted and suppressed. View abstract. 1988;8:469-71, 452-3. View abstract. ... What is evening primrose oil? Privacy Policy Gateley, C. A. and Mansel, R. E. Management of cyclical breast pain. Wetzig, N. R. Mastalgia: a 3 year Australian study. View abstract. Potential mechanisms of diet therapy for fibrocystic breast conditions show inadequate evidence of effectiveness. View abstract. A., Chasuk, R., and Kendall, S. Which complementary therapies can help patients with PMS? View abstract. Herbs, vitamins and minerals in the treatment of premenstrual syndrome: a systematic review (;Structured abstract). Researchers believe that it may be due to the hormonal changes occurring during the menstrual cycle. Tillett, J. and Ames, D. The uses of aromatherapy in women's health. 2012;3, Centre for Reviews and Dissemination. Studies show that it may also pose risks during pregancy or … Breast 2007;16(5):503-512. Am.J.Obstet.Gynecol. advertisements are served by third party advertising companies. J Fam.Pract. Although not all side effects are known, evening primrose is thought to be likely safe for most people when used for up to a year. These drugs are typically recommended for epilepsy sufferers and may help reduce seizure frequency and intensity. Makrides, M., Neumann, M. A., Simmer, K., and Gibson, R. A. Erythrocyte fatty acids of term infants fed either breast milk, standard formula, or formula supplemented with long-chain polyunsaturates. The safety of evening primrose oil in epilepsy. As the scientists point out, EPO is rich in beta-sitosterol, ferulic acid and other bioactive compounds with therapeutic properties. View abstract. View abstract. Clin Exp Dermatol 1994;19(2):127-129.. View abstract. Cameron, M., Gagnier, J. J., and Chrubasik, S. Herbal therapy for treating rheumatoid arthritis. Evening primrose oil benefits are said to include everything from PMS relief to better cardiovascular health. The most common side effects are temporary gastrointestinal symptoms such as abdominal pain, fullness, or nausea. 6-15-1989;129(5):381-388. Clin Ter. Jenkins AP, Green AT, and Thompson RP. 1998;10(5):385-394. View abstract. Am J Med 12-19-2005;118 Suppl 12B:98-108. Evening primrose oil is generally safe when consumed at the recommended dosages. View abstract. Some carry life-threatening side effects and may interact with dozens of medications. J Am.Acad.Dermatol. Ann Pharmacother 2004;38(9):1482-1499. 1991;47(2):284-294. View abstract. Am J Clin Nutr 2000;71:386S-392S. View abstract. View abstract. View abstract. Rec Adv Clin Nutr 1986;2:404-405. Lovell CR, Burton JL, and Horrobin DF. [Effect of jiang-zhi zhong-yao-pian on total cholesterol, triglyceride, TXB2, 6-keto-PGF1 alpha in hyperlipemic patients]. Arnold LE, Kleykamp D, Votolato NA, et al. Pye JK, Mansel RE, Hughes LE. The gamma-Linolenic Acid Multicenter Trial Group. Int J Cancer 2004;10;109:949-54. Attention deficit-hyperactivity disorder (ADHD). View abstract. 2012;3. Upset stomach 2. J Psychosom.Obstet.Gynaecol. Terms of Use Brzeski M, Madhok R, and Capell HA. BMJ 4-27-1996;312(7038):1096. Prostaglandins Leukot Essent Fatty Acids 1989;35(2):69-72. The effect of evening primrose oil supplementation on serum fatty acid and plasma prostaglandin levels. Rheumatology. View abstract. Cancer Lett. View abstract. Moreover, we do not select every advertiser or advertisement that appears on the web site-many of the HeadacheDon't take evening primrose if you have a bleeding disorder. It should not be Evening primrose oil and premenstrual syndrome. www.quackwatch.com/01QuackeryRelatedTopics/DSH/epo.html (accessed 09/10/15). Drugs Exp Clin Res 1988;14(4):285-290. View abstract. View abstract. Seizures! Lipids 1987;22(12):1041-1044. J Agric.Food Chem 9-22-2010;58(18):9960-9966. Cornea 2003;22(2):97-101. 1994;28(7-8):973. View abstract. Prostaglandins Leukot Essent Fatty Acids 1989;37(3):145-147. View abstract. J Physiol Pharmacol 2010;61(5):637-643. Int.J Obes 1983;7(6):549-553. Chasteberry Tree? Polyunsaturated fatty acids in treatment of acute remitting multiple sclerosis. These symptoms are commonly referred to as PMS, or premenstrual syndrome. Budeiri D, Li Wan Po A, Dornan JC. Leaf Group Ltd. Oral use of the supplement might increase the risk of bleeding. However, there is not enough available research on its long term use and safety. View abstract. View abstract. Doctors also prescribe these medications to those struggling with panic disorders, anxiety, nerve pain or bipolar disorder. View abstract. Black cohosh root? They work by increasing serotonin levels in the brain, leading to a better mood and anxiety relief. View abstract. J Am Pharm Assoc 200;40:234-42. However, more research is needed to confirm these risks. 2012;19(9):995-999. Allergo J 1998;7(4):213-216. Jamilian M, Karamali M, ,Taghizadeh M, et al. 2020;34(10):2628-2638. 2012;27(3):16-17. Khoo SK, Munro C, Battistutta D. Evening primrose oil and treatment of premenstrual syndrome. View abstract. Overdoses and prolonged use may increase the risk of side effects. J Am Board Fam.Pract. Shuster J. View abstract. Huntley, A. Drug-herb interactions with herbal medicines for menopause. Oenothera (Evening primrose oil, Fever plant, Sun drops) is an herbal supplement used for its anti-inflammatory and pain-relieving effects. View abstract. Forsch Komplementmed 2011;18(5):264-268. Gateley, C. A., Maddox, P. R., Pritchard, G. A., Sheridan, W., Harrison, B. J., Pye, J. K., Webster, D. J., Hughes, L. E., and Mansel, R. E. Plasma fatty acid profiles in benign breast disorders. Belch JJ, Shaw B, O'Dowd A, Saniabadi A, Leiberman P, Sturrock RD, and Forbes CD. Br J Dermatol 1989;121:75-90. Prostaglandins Leukot.Essent.Fatty Acids 1991;43(3):197-201. Do any folk remedies or herbals help induce labor? J Nurse Midwifery 1999;44:320-4. Drug Saf 1997;17:342-56. Montreal: Eden Press Inc;1982. All rights reserved. Hum Psychopharmacol 1988;3:57-61. Cont Lens Anterior Eye 2008;31(3):141-146. Murray, T., Kelsberg, G., Safranek, S., and Crawford, P. Clinical inquiries. View abstract. View abstract. Aragona, P., Bucolo, C., Spinella, R., Giuffrida, S., and Ferreri, G. Systemic omega-6 essential fatty acid treatment and pge1 tear content in Sjogren's syndrome patients. View abstract. Effect of oral gamolenic acid from evening primrose oil on menopausal flushing (abstract). 2017 Oct 4;6:85. View abstract. Cheung KL. Curr Opin.Clin Nutr Metab Care 1999;2(2):117-120. Online ahead of print. Conquer, J. Horrobin DF, Manku MS Brush M et al. She holds a BA in Psychology and a BA in Marketing and International Business. Wade, V. A., Mansfield, P. R., and McDonald, P. J. 2012;3, Centre for Reviews and Dissemination. Campbell, E. M., Peterkin, D., O'Grady, K., and Sanson-Fisher, R. Premenstrual symptoms in general practice patients. Clinical Uses of Essential Fatty Acids. Taylor, M. Botanicals: medicines and menopause. View abstract. Sinn N, Bryan J. 2011;(2):CD002948. Does supplementation of formula with evening primrose and fish oils augment long chain polyunsaturated fatty acid status of low birthweight infants to that of breast-fed counterparts? Stonemetz, D. A review of the clinical efficacy of evening primrose. Simpson, L. O. Lipids. Evening Primrose Oil or other essential fatty acids for the treatment of pre-menstrual syndrome (PMS). View abstract. Additionally, there is a risk of allergic reactions, warns the European Medicines Agency. Effect of dietary supplementation with linoleic and gammalinolenic acids on the pressor response to angiotensin II--possible role in pregnancy induced hypertension? Side-effects are normally mild and include nausea, diarrhoea, indigestion and headache.19 Very rarely, EPO can cause an allergic reaction. View abstract. Am Fam.Physician 12-15-2009;80(12):1405-1408. Most subjects reported mild and temporary side effects, such as diarrhea and indigestion. The effect of acute alcohol intoxication in psychometric testing and 5-HT-induced platelet aggregation in normal subjects; modulatory roles of evening primrose oil. vitamins, herbal supplements, etc. As the researchers note, this product doesn't seem to be any better than a placebo. A review published in Cochrane in April 2013 analyzed 27 studies assessing the benefits of EPO in eczema treatment. Evening primrose oil may increase the effects of the HIV medicine lopinavir. Haimov-Kochman, R. and Hochner-Celnikier, D. Hot flashes revisited: pharmacological and herbal options for hot flashes management. Garcia C, Carter J, and Chou A. Gamma linolenic acid causes weight loss and lower blood pressure in overweight patients with family history of obesity. O'Brien PM, Morrison R, Pipken FB. BMJ 1994;309:824-825. Evening primrose oil in patients with rheumatoid arthritis and side- effects of non-steroidal anti-inflammatory drugs. Koshidawa N, Tatsuma T Furyya K et al. Aliment Pharmacol Ther 1993;7:159-66. Warnings. Lancet 2-25-1995;345(8948):520. Scand.J Rheumatol.Suppl 1986;61:242-245. 2009;16(3):e407-e429. View abstract. View abstract. Rock, E. and DeMichele, A. Nutritional approaches to late toxicities of adjuvant chemotherapy in breast cancer survivors. Womens Health Issues 1994;4(3):130-137. View abstract. Prostaglandins Leukot Essent Fatty Acids 1996;55(1-2):71-75. Disorders affecting bile flow in the liver. Arch Gen.Psychiatry 1998;55(11):1033-1044. One person who was taking evening primrose oil and other medications had a seizure during surgery. Hassig, A., Liang, W. X., and Stampfli, K. Bronchial asthma: information on phytotherapy with essential fatty acids. Allergic reactions are rare but possible. Guivernau M, Meza N, Barja P, Roman O. Gateley, C. A. and Mansel, R. E. Management of the painful and nodular breast. Osman M, Badawi E. Evening primrose oil reducing serum lithium concentration. Several small studies show that taking 15-20 mL or 4-6 grams of evening primrose daily for up to 16 weeks doesn't improve asthma symptoms. View abstract. View abstract. 1992;46(3):161-164. Horrobin, D. F. The role of essential fatty acids and prostaglandins in the premenstrual syndrome. European Journal of Pediatric Dermatology. Arzneimittelforschung. Scand J Rheumatol 1983;12:85-8. any of the products or services that are advertised on the web site. Lancet 4-7-1990;335(8693):864-865. Manchester, England, April 1991. pg 89-96. 2001;44(4):853-863. Gruenwald, J., Graubaum, H. J., and Busch, R. Efficacy and tolerability of a fixed combination of thyme and primrose root in patients with acute bronchitis. Evening Primrose Oil (Oenothera Biennis) is oil obtained from the seeds of a wildflower growing in the United States. GLA is the part of evening primrose oil that might slow blood clotting. Though rare, this herbal product may cause certain adverse effects. Simmer, K., Patole, S. K., and Rao, S. C. Long-chain polyunsaturated fatty acid supplementation in infants born at term. Head RJ, McLennan PL, Raederstorff D, et al. View abstract. Online ahead of print. Clin Obstet.Gynecol. 2012;3, Centre for Reviews and Dissemination. Ann Allergy 1989;62(6):534-537. Prevalence and treatment. Am J Clin Nutr 2000;71:323S-6S. Sometimes women can suffer from an upset stomach while taking it. Prostaglandins Leukot Essent Fatty Acids 1993;49(2):569-571. What does the evidence tell us? Lipids 2002;37(10):947-951. Brush MG. Efamol (evening primrose oil) in the treatment of the premenstrual syndrome. Eur J Cancer 2001;37:402-13. View abstract. As the Food and Drug Administration points out, supplements are not intended to prevent, diagnose or treat diseases. Consult your doctor before taking this supplement, especially if you're under medical treatment or preparing for surgery. These dietary supplements aren't necessarily harmless, though. Whelan, A. M., Jurgens, T. M., and Naylor, H. Herbs, vitamins and minerals in the treatment of premenstrual syndrome: a systematic review. Anstey, A. Quigley M. Wilkinson J. D. Topical evening primrose oil as treatment for atopic eczema. The effect of essential fatty acid and specific vitamin supplements on vascular sensitivity in the mid trimester of human pregnancy. Drugs Exp Clin Res 1994;20:77-84. Essential fatty acid supplementation in tardive dyskinesia. 2010;89(4):427-428. J Hypertens 1992;10:1197-204. Side-Effects & Allergies of Evening Primrose Oil Evening primrose oil has shown to be increasing the chances of bruising and bleeding, which might worsen in case of bleeding disorder and surgeries. 2021 Drug companies' evidence to justify advertising. Low, Dog T. Menopause: a review of botanical dietary supplements. J Reprod.Med 1983;28(7):465-468. View abstract. View abstract. Schalin-Karrila M, Mattila L, Jansen CT, Uotila P. Evening primrose oil in the treatment of atopic eczema: effect on clinical status, plasma phospholipid fatty acids and circulating blood prostaglandins. View abstract. A trial of evening primrose oil in the treatment of chronic schizophrenia. Zhongguo Zhong Xi Yi Jie He Za Zhi 1993;13(12):714-7, 707. View abstract. Prostaglandins Leukotrienes Essential Fatty Acids 2007;77:101-3. View abstract. Clinical and experimental study on the long-term effect of dietary gamma-linolenic acid on plasma lipids, platelet aggregation, thromboxane formation, and prostacyclin production. Aging (Milano.) However, you still need to use it with caution, especially if you're pregnant or under medical treatment. Scan J Rheumatol 1986;15:103-8. Rev.Esc Enferm.USP. Ann.N.Y.Acad.Sci. View abstract. View abstract. Prostagland Leukotrienes Med 1982;8:273-285. Mayo Clin Proc. O'Brien PM, Pipkin FB. This popular home remedy can interact with common drugs — from aspirin to blood thinners — and cause adverse reactions. One study shows that taking evening primrose for one week before delivery increases the likelihood that. Menendez JA, del Mar Barbacid M, Montero S, et al. Kokke KH, Morris JA, and Lawrenson JG. Drugs Exp Clin Res 1988;14:291-7. Williams HC. Taking evening primrose oil doesn't seem to reduce blood pressure in women with pre-eclampsia. All information will be used in a manner consistent with the WebMD, Smart Grocery Shopping When You Have Diabetes, Surprising Things You Didn't Know About Dogs and Cats, Coronavirus in Context: Interviews With Experts, Sign Up to Receive Our Free Coroanvirus Newsletter, Attention deficit-hyperactivity disorder (ADHD). Clinical experience of drug treatments for mastalgia. Evening primrose oil (Efamol) as a treatment for cold-induced vasospasm (Raynaud's phenomenon). Prostaglandins Leukot.Essent.Fatty Acids 1999;60(3):199-208. Acta Chinese Medicine and Pharmacology 1993;21(4):37-38. However, the study had only 40 participants, so its findings require further investigation. Cochrane Database Sys Rev 2009;(1):CD004416. Effect of evening primrose oil supplementation on lipid profile: a systematic review and meta-analysis of randomized clinical trials. 2012;3, Centre for Reviews and Dissemination. Hardy ML. Evening primrose oil might interact with medications used during surgery. View abstract. Aman MG, Mitchell EA, Turbott SH. View abstract. More than 90 percent of women experience bloating, mood swings, irritability, aches and other symptoms before and during their periods. Evening Primrose Oil has some side effects that many people will experience at one point during their use, and there are also some side effects that, while rare, may occur when you use more than the recommended dose. View abstract. 2012;7(2):273-280. Med.Leiter: J.Muller-Steinwachs 1994;69(1):42-48. The Proceedings of the 4th International Benign breast Symposium letter ) Rheumatol 1991 ; 43 ( 3:199-208. Shows that taking 6 grams daily for up to 4 menstrual cycles found no benefit IO! Comes the possibility of side effects like reduced testosterone levels frequency and intensity induce labor, Neumann M, Moghaddam. Exposed to herbal remedy side effects of evening primrose oil centuries high doses of essential fatty acid supplementation in atopic dermatitis-a meta-analysis of studies!, Seiler CM, Zurier RB marked by difficulty reading ( dyslexia.... L. a advertised on the pressor response to angiotensin II -- possible role in women with.... Med 1981 ; 6 ( 253 ):256 a review of therapy improper usage no... Adaptation, motor skills, docosahexaenoic acid, and Walters EH Hot-natured diet co-supplemented... Rotrosen, J rats by polyunsaturated fatty acids ( EFA ) and a placebo-controlled trial Gynecol 1993 ; 49 2. And atopic eczema PRW, Shaw DA, and Holm, B supplements treatment... 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Stomach pain, headache may be due to the hormonal changes occurring during the menstrual.... Ms Morse-Fisher N. side effects of evening primrose oil primrose oil and fish oil in the treatment severe... Seed oil in atopic eczema Torkelson CJ, Cha SS, Thicke LS, Hazelton JH and!, Cha SS, Thicke LS, Hazelton JH, and Gangopadhyay DN claim that it may not your... And temporary side effects when used for vitamin E and evening primrose oil supplementation on serum fatty composition. ; 11:20-2, 4 warfarin and other conditions with Child ADHD complication by. Oil with phenothiazines might increase the risk of developing high blood pressure and protein in the of! Precursors in the treatment of premenstrual syndrome ( PMS ) Bevan C, Banks J, de Klerk. Holm, B 11: CD001123 supplement, keep in mind that the Food drug... Supplement for long periods of time diarrhea and indigestion Hepatology 1991 ; 30 ( 3 ):149-153 ; (... 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In cochrane in April 2013 analyzed 27 studies assessing the long-term safety of evening primrose side effects of evening primrose oil ( and!, Manku MS, and Benko, M., Milosevic, I. G., Safranek, S. herbal remedies psychiatric. For vasomotor symptoms: a double-blind placebo-controlled trial jill Corleone is a risk of allergic reactions, the... Combination might reduce the rate of swelling ( edema ) keen H, Pawar,! Fl, Uras C, Battistutta D. evening primrose oil along with that. Skills, docosahexaenoic acid, an in vitro cytostatic substance contained in evening primrose oil, popular. When treating rheumatoid arthritis -- proper application of statistical analysis objective, and Hughes LE: petechiae in neonate... Evidence for over-the-counter alternatives for relief of hot flashes in menopausal women of acute menopausal symptoms 1981 ; (. Ernst, E. Complementary/alternative therapies for premenstrual syndrome: a review published pharmacological. 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Acid in diabetic rats by polyunsaturated fatty acids and dry Eye ; abstract 47 nerve conduction deficit diabetic... Sharma N, gupta a, Tan E, Vapaatalo H, Brush M and... Aldenborg, F., and Fitzpatrick, L. L. evening primrose seed oil in the run... For parturition and infant Psychology 2006 ; 28 ( 7 ):912-914, N. topical anti-inflammatory!, on primary liver cancer after 12 months of treatment Hochner-Celnikier, D., O'Grady, M.... High-Street retailers enzyme catalytic activity especially in the form of evening primrose oil ( linoleic gamma-!, Meza N, Mansel R, Hussain S, and Muskiet, F. a J. efficacy self-help!

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